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KMID : 1001020210190020101
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Journal of Urologic Oncology
2021 Volume.19 No. 2 p.101 ~ p.108
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Utility of Next-Generation Sequencing for Deciphering Intratumor Heterogeneity in Prostate Cancer
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Joung Je-Gun
Park Joo-Young
Yang So-Yun
Jeong Jeong-Yun
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Abstract
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Prostate cancer has long been considered a disease with a heterogeneous phenotype. The intratumor heterogeneity (ITH) may affect diverse phenotypes such as treatment response, drug resistance, and overall clinical outcomes. Despite technical advances over the past decade, we have an incomplete understanding of the extent and effects of ITH in prostate cancer progression.
We present here a comprehensive review of the various studies dealing with ITH in prostate cancer. We discuss the advanced next-generation sequencing analyses including single cell sequencing and circulating cell-free DNA sequencing that have the impact of heterogeneity on clinical decision making.
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KEYWORD
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Prostate cancer, Intratumor heterogeneity, Next-generation sequencing, Clonality, Genomic marker
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